A) Palestinians who lived there
B) Rule by Arab nations
C) Legacy of ottoman control
D) Scarcity of water and other resources
Chargaff's Rule, stating that in DNA the amount of adenine equals thymine and guanine equals cytosine, guided Watson and Crick in formulating the double helix DNA model. The model involves two polynucleotide chains twisted together, with specific base pairings as suggested by Chargaff's Rule, enabling semi-conservative replication.
Chargaff's Rule, named after biochemist Erwin Chargaff, postulates that in any sample of DNA, the amount of adenine (A) is equal to that of thymine (T), and the amount of guanine (G) equals the amount of cytosine (C). This observation is often represented as A=T and G=C. This equality arises from the specific pairing of these bases in the DNA double helix structure, whereby A always pairs with T and G with C.
This principle was critical in guiding James Watson and Francis Crick in their proposal of the double helix model of DNA. The model explained that DNA consists of two polynucleotide chains running antiparallel and twisting around each other, with the specific base pairing noted in Chargaff's Rule. This allows for the semi-conservative replication of DNA, where half of the parent DNA molecule is conserved in each of the two daughter DNA molecules following replication.
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