Histamine is a chemical substance released in inflammatory and allergic responses. The histamine H1 receptor on target cells is a G protein-coupled receptor that activates phospholipase C in response to the binding of histamine. Which statements are true about the binding of histamine to the histamine H1 receptor? Select all that apply. Histamine diffuses across the plasma membrane to bind to the H1 receptor. Histamine binds extracellularly to the H1 receptor. When histamine binds to the H1 receptor, the receptor undergoes a conformation change and binds the inactive G protein. Histamine binds intracellularly to the inactive G protein, activating the G protein. Once the G protein is active, it binds to the enzyme phospholipase C, activating it. Histamine is likely hydrophilic.

Answers

Answer 1
Answer:

The statements 'histamine binds extracellularly to the H1 receptor', 'when histamine binds to the H1 receptor, the receptor undergoes a conformation change and binds the inactive G protein', 'once the G protein is active, it binds to the enzyme phospholipase C, activating it', and 'histamine is likely hydrophilic' are TRUE.

Histamine is a molecule released during inflammatory and allergic responses.

This molecule (histamine) binds to the G-protein coupled histamine (H1) receptor. This binding triggers a conformational change in the three-dimensional (3D) shape of the G-protein coupled H1 receptor.

Subsequently, the heterodimeric G protein is activated by GTP binding. The G-protein–GTP complex then dissociates from the G-protein coupled H1 receptor and interacts with phospholipase C, thereby activating a transduction signaling pathway.

Finally, the G protein accelerates the hydrolysis of GTP to GDP and thus terminates the transduced signal.

In conclusion, the statements 'histamine binds extracellularly to the H1 receptor', 'when histamine binds to the H1 receptor, the receptor undergoes a conformation change and binds the inactive G protein', 'once the G protein is active, it binds to the enzyme phospholipase C, activating it', and 'histamine is likely hydrophilic' are TRUE.

Learn more in:

brainly.com/question/7034483?referrer=searchResults

Answer 2
Answer:

Answer:

-Histamine binds extracellularly to the H1 receptor.

-When histamine binds to the H1 receptor. the receptor undergoes a conformation change and binds the inactive G protein.

-Once the G protein is active, it binds to the enzyme phospholipase C, activating it.

-Histamine is likely hydrophilic.

When histamine encounters a target cell, it binds extracellularly to the H1 receptor, causing a change in the shape of the receptor. This change in shape allows the G protein to bind to the H1 receptor, causing a GTP molecule to displace a GDP molecule and activating the G protein. The active G protein dissociates from the H1 receptor and binds to the enzyme phospholipase C, activating it. The active phospholipase C triggers a cellular response. The G protein then functions as a GTPase and hydrolyzes the GTP to GDP. The G protein dissociates from the enzyme and is inactive again and ready for reuse.

Explanation:


Related Questions

Fill in the blanks. The cytochrome b6f is a large multisubunit protein, which accepts electrons from the __________________ . One electron moves linearly toward ____________, while the other goes through a cyclic process, which effectively pumps more ___________ into the thylakoid lumen.
Marion lives on the streets. She doesn't make much sense when she talks, and she believes that people in the sidewalk are watching her. She probably suffers from:A. an anxiety disorder. B. bipolar disorder. C. a dissociative disorder. D. schizophrenia.
___________ can be used by cells to store energy, form biological membranes, and serve as chemical messengers.
In a active transport materials move from an area of ? Concentration and use ?
What process restores the 2N chromosome number in a zygote's somatic cells for growth and development to continue?

Glucose is not able to pass through a semi-permeable cell membrane. If the cells need sugar to make ATP and carry out cellular processes, how does the sugar get into the cell?A) passive transport by diffusion through proteins
B) active transport using ATP and carrier proteins
C) passive transport by osmosis through the proteins
D) active transport using a process called phagocytosis

Answers

The correct option is passive transport by diffusion through proteins.

What is passive transport?

A type of cellular transport known as passive transport involves the movement of molecules and ions along concentration gradients. It indicates that a drug has a propensity to migrate from a region of higher concentration to a region of lower concentration.

Contrary to active transport, another type of cellular transport, which fundamentally requires ATP to move substances against their concentration gradient, the process does not require metabolic energy (e.g. ATP) because the chemicals are moved downhill or along their concentration gradient.

The four main methods of passive transport are osmosis, filtration, simple diffusion, and assisted diffusion.

Therefore, The correct option is passive transport by diffusion through proteins.

To learn more about active transport, refer to the link:

brainly.com/question/12133248

#SPJ6

A) passive transport by diffusion through proteins

Is there a breed of male cows that have udders?

Answers

Answer:

Bull and cow not have udders

Explanation:

Thats

Final answer:

No, there is no breed of male cows that have udders. Udders are mammary glands found in female cows, and their purpose is to produce milk. The udders of female cows are an important reproductive feature that allows them to nourish their young with milk after giving birth.

Explanation:

No, there is no breed of male cows that have udders.

Udders are mammary glands found in female cows, and their purpose is to produce milk. Male cows, also known as bulls, do not have udders because they do not produce milk.

The udders of female cows are an important reproductive feature that allows them to nourish their young with milk after giving birth.

Learn more about Udders in cows here:

brainly.com/question/37666035

#SPJ11

Which important macromolecule plays a role in speeding up processes that 1 pointtypically would take a long time *
Triglycerides
Glucose
Enzymes
RNA

Answers

Enzymes because they are the catalyst of the reaction process.

The sympathetic nervous system controls all _________ responses of the body. a. conscious
b. involuntary
c. emergency
d. repeated

Answers

I believe the correct answer from the choices listed above is option C.The sympathetic nervous system controls all  emergency  responses of the body. The SNS triggers what is commonly known as the "fight or flight" response. Hope this answers the question.

A ______ frequency causes a _____wavelength and ______ energy. Lesson: 4.09 Question 10 options: higher, shorter, high low, shorter, greater low, greater, shorter higher, greater, shorter

Answers

Answer:

A higher frequency causes a shorter wavelength and higher energy.

A shorter frequency causes a greater wavelength and low energy.

Explanation:

Frequency is the number of waves that move at a period of time. It is measured by counting the number of crest point.

Wavelength is the distance between waves. A wave with higher frequency have crest that a very close and therefore the distance between them or wavelength is short compare to a wave with low frequency that the distance are farther apart and they have long wavelength. Therefore to generate high frequency of wave , more energy is required to do this .

Match each feature you created by erosion to the correct description. (Edugenity)

Answers

Answer:TRIBUTARY-one of many channels that connect to form a river

RILL-a small groove in soil created by runnoff STREAM-a series of connected channels that fills with water GULLY-a channel of created by runoff

Explanation:

I got it correct

i don’t know dvbdbdbsbdbdbdbdbdbbdbfbxbxbdbdbdbdbdbxbxbxj